P-Acne Bacteria & Acne Biofilms

In my last post we talked about retention hyperkeratosis being the cause for acne. Read here: Retention Hyperkeratosis 

 P-Acnes Bacteria

For the longest time it was believed that the Propionibacterium acnes (p-acnes bacteria) were the cause of acne. We know now that these bacteria exist in the pores of every human being, and do not dwell in greater numbers in acne-prone people. P- acne bacteria are anaerobic bacteria, which means they thrive without the presence of oxygen. So when the follicle swells and dead skin cells cover the opening of the follicle, the bacteria start to party.  The party starts by  the bacteria feeding off of triglycerides produced by our sebaceous glands.  They then excrete an enzyme called lipase to split the oil into fatty acids and glycerol.  They devour the glycerol portion, the part that they like, and discard the fatty acid byproducts.  The problem with the bacterial action is that the fatty acids, which the bacteria create and then discard as garbage, are quite irritating to the pores and aggravate acne.

These digestive enzymes also destabilize the layers of cells that form the wall of the follicle. The cellular damage, metabolic by-products, and bacterial debris produced by the rapid growth of p.acnes trigger inflammation.  When these digestive enzymes spiral out of control for too long, they destroy the follicle so much that it breaks, and leaks out infection into the other areas of the skin.  This is shown by the presence of cysts and nodules.  

There Are Two Forms of P-Acnes Bacteria

1) Gram-Positive Bacteria
2) Gram-Negative Bactera

The damage caused by P-acnes and the associated inflammation make the affected tissue more susceptible to colonization by opportunistic bacteria such as Staphylococcus Aureus.
Research shows that only healthy pores are colonized by P-acnes, while unhealthy ones universally include the nonpore-resistant Staphylococcus Epidermidis.

There are types of acne caused by gram negative bacteria.  Gram negative bacteria have the potential to secrete toxic byproducts which can cause intense inflammation and infection. Gram negative folliculitis is a bacterial infection present in pustules, cysts, and nodules. Unfortunately, gram-negative bacteria are resistant to most antibiotics. If you take antibiotics for too long, it causes bacterial interference.  The gram positive bacteria that proliferates in your nasal cavities and mucous membranes can turn into gram negative bacteria.

Tea tree oil only kills gram positive bacteria.  Mandelic acid kills gram negative bacteria along with licorice root, black cumin oil, and manuka oil.  Mangolia extract and mandelic acid kill both p acnes bacteria.

Symptomes & Appearance of Gram- Negative Folliculitis

 Sudden increase in the number and severity of acne lesions despite antibacterial treatment.  Sufferers who previously had whiteheads and blackheads will start developing numerous cysts, pustules, and nodules.  They will develop large clusters of nodules, cystic lesions that burrow and interconnect. Skin appears red, inflamed, irregular, and painful to touch.

Acne Biofilm

Part of the reason why cells stick together in the follicle is due to p-acne biofilm. Biofilms produce irritant fatty acids that promote inflammation and enhance p.acnes adhesion to the sebaceous follicle.

P- acne bacteria reside in the pilosebaceous unit in a biofilm, which means they live in a community that encases itself in an extra cellular lining to survive. Research is showing that the biofilm may explain the development of retention hyperkeratosis as they cause the keratinocytes to be very sticky. It may also explain the immunogenicity of the organism as well as the clinical course of the disease.  The biofilm is a new discovery.  We are not sure if it has always been there or is something that happened to resist antibiotics and other treatments.